The first step is to palpate and identify the area of plaque formation. The previously identified point of maximal curvature (during curvature assessment) can be used as a point of reference. The penis should be placed on good stretch (with an assistant) and the skin prepped with alcohol swab. Using the nondominant hand grasp the plaque and the dominant hand can begin injecting into the plaque moving in a fashion to create rows of injection (Figs. 12.2, 12.3, 12.4, 12.5, 12.6, 12.7, and 12.8). The needle does not have to be withdrawn from the skin after each injection, only when needed to fully treat the plaque. For a ventral curvature, the injections are performed lateral to the urethra in a series of rows much like the dorsal technique (Figs. 12.9, 12.10, 12.11, 12.12, 12.13, and 12.14). Hold pressure for 3 min over the injected region to minimize hematoma formation.