Future Directions in Understanding Nausea and Vomiting


Better characterization of neural pathways and receptors mediating sensation of nausea and vomiting:

 Gender differences

 Similarities and differences for nausea compared to vomiting

 Similarities and differences for different disorders

  CINV vs. NVP vs. Gastroparesis, CUNV, CVS

 Development of animal models for nausea

Improving evaluation of patients with chronic nausea and vomiting:

 What is proper evaluation of patients with nausea and vomiting

 Different specialties perform different tests and treat differently

 Better definition for nausea

 Determining relationships of gastric dysmotility to symptoms of nausea and vomiting

Improving treatments:

 Are antiemetics also antinauseants

 How well do antinauseants and antiemetics used in one condition work in another

 Use of CNS imaging to demonstrate the therapeutic action of therapeutic agents

 Use of pharmacogenomics to guide treatment choices and dosing of antiemetics

 Targeting the gastric ENS/ICC as treatment

Enhancing Drug development:

 Improve outcome measures for clinical trials

  Nausea

  Vomiting

 Explore use of agents for treatment of nausea and vomiting that are approved for other disorders

  Toperimate

  Olanzepine

  Mirtazepine

  Buspiorone

  Gabapentin

  Corticosteroids

  Cannabinoids

 Expand use of agents approved for CINV to treatment of nausea and vomiting from other disorders

  5-HT3 receptor antagonists

  NK1 receptor antagonists


CINV chemotherapy-induced nausea and vomiting, NVP nausea and vomiting of pregnancy, CUNV chronic unexplained nausea and vomiting, CVS cyclic vomiting syndrome, CNS central nervous system, ENS enteric nervous system, ICC interstitial cells of Cajal



The neural pathways and receptors mediating the sensation of nausea need better characterization. For example, are the neural pathways the same for nausea as for vomiting? Since gastroparesis is much more common in women than in men, what gender differences are present in the relevant neural pathways that result in nausea? How similar or different are the pathways mediating nausea for different disorders, such as gastroparesis or cyclic vomiting syndrome. Is vomiting elicited differently in these disorders? Do agents that are efficacious for CINV also improve nausea and vomiting from gastrointestinal disorders? Should more of these agents be evaluated in GI diseases with prominent nausea and vomiting? In addition, are the pathways mediating nausea and vomiting in GI disorders, such gastroparesis or gastroparesis-like syndromes, similar to that for cyclic vomiting syndrome? To study the pathways in nausea and vomiting, animal models need to be developed. The shrew is an animal model in which vomiting can be studied. Currently, nausea is assessed only indirectly in animal models.

What is the proper clinical evaluation for these patients with nausea and vomiting? Currently, patients may seek care for their symptoms from their family medicine physician or internist and are then often referred to either a gastroenterologist, neurologist, or ENT physician. Each type of specialty might perform different tests and might treat patients differently. Better understanding of the evaluation of patients with chronic nausea and vomiting by different physicians may be helpful for all physicians. One area that is emerging is that for patients with gastroparesis, the symptoms do not correlate well with gastric emptying delays. Perhaps the symptoms that we attribute to delayed gastric emptying are from other gastric causes or non-gastric causes as reviewed in Chaps. 1, 3, and 4.

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Nov 6, 2017 | Posted by in GASTROENTEROLOGY | Comments Off on Future Directions in Understanding Nausea and Vomiting

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