(1)
Department of Child Health, University of Missouri, Columbia, MO, USA
Pain in children, especially chronic pain, challenges the diagnostic acum, therapeutic skill, and personal mettle of the physician…. The clinician must deal with fact, fancy, and feelings; conscious and unconscious processes; the parents as well as the child; and with psychologic as well as drug therapy.
Morris Green [1]
Chapter Outline
Introduction
Features of the Recurrent Abdominal Pain Syndrome (RAPS)
Management of RAPS: Clarity, Effective Reassurance, Continuity and
Accessibility of care
Psychosocial Aspects of Management
Functional Abdominal Pain Crises:
Defining characteristics
Family dynamics
Outpatient management
Inpatient management
Introduction
Recurrent abdominal pain of obscure origin is prevalent in 12–28 % of school children [2] and is one of the commonest problems encountered by physicians who care for children [3, 4]. Functional recurrent abdominal pain poses two challenges for the clinician: First is the problem of identifying the cause of a symptom that has a large differential diagnosis [5]. Second is the problem of how to be helpful to patients whose symptoms are not caused by identifiable organic disease and cannot be consistently relieved by medications, diets, or surgery.
The recurrent abdominal pain syndrome (RAPS), abdominal migraine, and the abdominal pain that accompanies acute anxiety or panic [6] are examples of functional abdominal pain. The mechanisms by which they are produced are not completely understood. Are they produced by distinctly different, overlapping, or the same mechanisms? The pains are felt in the abdomen, but where are they generated, in the abdomen, the brain or both? These unanswered questions notwithstanding, the above examples of functional abdominal pain each have characteristic clinical features that allow for positive, diagnosis-specific management.
Features of the Recurrent Abdominal Pain Syndrome (RAPS)
RAPS is prevalent in about 10 % of school-aged children in general, and up to 28 % of girls between 9 and 12 years of age [4, 7] (Fig. 4.1).
Fig. 4.1
The prevalence of recurrent abdominal pain in Apley’s survey of 1,000 unselected school children [7]. In boys from 5 to 10 years of age, there was a fairly constant prevalence of RAP between 10 and 12 %, then a fall, followed by a late peak around 14 years of age. In girls, the prevalence was similar, followed by a marked increase in girls between 9 and 12 years of age, followed by a steady decline in prevalence
The age of onset of pains peaks for both boys and girls at about 5 years. The incidence peaks again for girls around pubescence (9–12 years of age) [7, 8] (Fig. 4.2).
Fig. 4.2
The incidence of RAP in Apley’s school series [7]: In both sexes, there was a steady increase in the number of cases beginning in each year up to the age of 5. The number of boys developing pain then fell, but in girls, there was a further striking increase between 8 and 10 years of age
The quality and location of pains. Attempts have been made to characterize Recurrent Abdominal Pain Syndrome as having either dyspeptic or irritable bowel patterns [3]. Dyspeptic symptoms consist of intermittent pain or burning localized to the epigastrium, not related to the urge to pass stool or flatus and not fulfilling criteria for biliary tract disorders [3]. Irritable Bowel Syndrome (IBS) pains are related to defecation and/or are associated with the change in the frequency and/or form of stools [3]. Whereas the typical location of dyspeptic symptoms is the epigastrium, the pain of Irritable Bowel Syndrome is typically mid- or lower abdominal.
A review of the charts of 100 of my patients referred for RAPS, chosen at random, revealed that the descriptions of pain quality conformed to dyspepsia in 12 patients, IBS in 38 patients, and both Dyspeptic and Irritable Bowel in 15 patients. Notably, 30 patients could not characterize their pain. (There was insufficient data for five patients.) The mid-abdominal location predominated in both children whose symptoms conformed to the Dyspeptic and to the Irritable Bowel patterns as well as children whose pains had features of both. Therefore, the pain of RAPS is typically mid-abdominal, less frequently epigastric [8] and therefore cannot be unequivocally classified as either dyspepsia or IBS in many patients.
Intensity of pains: Pain intensity is often so mild that the child’s activity and appearance are unchanged; or the pain can be severe enough to cause the child to lie down, become pale and temporarily incapacitated. It is rare for an episode of pain to occur during the consultative visit.
Precipitants of pains: About two-thirds of patients report that their pains are precipitated by heightened emotional states, respiratory infections, or eating [7, 8].
Temporal pattern of abdominal pain complaints: Pain complaints may be heard at any time during waking hours, especially before leaving for school, around dinner time, or at bedtime [8]. A key diagnostic feature of RAPS is that, regardless of how often or severe the pain is while the child is awake, it seldom interrupts the child’s sleep [8, 9]. When parents are asked whether their child has ever been awakened from sleep by his or her pain, most answer “no.” When the answer is “yes,” I try to assess whether the nocturnal awakenings with alleged abdominal pain occur as often, much less often, or only rarely compared with the frequency with pain complaints during waking hours. Most indicate that nocturnal awakenings are rare, e.g., 0–4 times during the preceding few months in a child who might complain of pain during waking hours on an almost daily basis. In the few cases in which nocturnal awakenings are said to be frequent, I ask for a description of the child’s behavior when awake and the nature and rapidity of his or her response to being comforted (e.g., being allowed into the parents’ bed or being accompanied back to his or her own bed by mother.) If there is behavioral evidence of emotional upset, such as a nightmare or other emotional cause for interrupted sleep, then it is likely that the child is using “tummy ache” as a code word for emotional distress. Children have difficulty distinguishing bodily pain from emotional distress and may use a familiar complaint that evokes parental concern to elicit the comforting they may truly need for relief of their emotional distress. If, on the other hand, the frequency of nocturnal pain complaints and the child’s response to parental comforting suggests actual bodily pain, then an organic cause for the complaint is more likely and must be investigated.
Family history: A history of functional gastrointestinal symptoms is eight times as common in first degree relatives of children with RAPS compared with relatives of the children who do not have RAPS [7].
Review of systems: Functional, autonomically mediated symptoms (such as a tendency to vomit easily, susceptibility to motion sickness, pallor without anemia, orthostatic lightheadedness) are common in patients with RAPS [7].
Physical findings: Physical exam is negative for signs of disease. There may be mild tenderness without guarding in one or both lower quadrants of the abdomen [8]. Deep palpation of the left iliac fossa may reveal a firm “slippery rope”-like segment of colon, which may contain lumps of segmented stool.
Management
Ordinarily, management of RAPS is accomplished by eliciting a comprehensive history in the context of good rapport, performance of a gentle but through physical examination, a urinalysis and the conveyance of three essential communications (which were presented in the Introductory Chapter’s section, “The Form and Content of Consultations,” and are reiterated here as applied to RAPS). These communications aim to satisfy the cogitative and emotional needs created by the child’s illness (see Table 4.1).
Table 4.1
The three essential communications
Understanding the Symptoms |
What is the diagnosis? And what creates the pain? |
Is the condition safe or dangerous? |
What can be done to relieve the pain? |
Can the condition be cured? Will it resolve quickly or will recovery take time? |
Effective Reassurance |
Continuity and Accessibility of Care |
Understanding the Symptoms
Naming a diagnosis helps by implying that the child’s symptoms conform to a recognizable pattern. Apley’s prevalence data [7] may be used to convince the parent’s that RAPS is common, and therefore not unique, puzzling or ominous. The pains can be attributed to functional gut irritability and spasm. An analogy can be made with skeletal muscles spasm, such as a runner’s leg cramp: both can be quite painful, but neither is caused by disease or causes damage, and both are self-limited. Often the parents themselves and/or other family members have had IBS symptoms they can relate to. This addresses the safety of the pains.
As for what to do to alleviate an especially severe pain, the first remedy is to sit down or lie down in a peaceful, quiet place, perhaps apply a heating pad to the abdomen, and expect to the brunt of the pain to pass within 30 min. If the pain does not subside soon, an anticholinergic antispasmodic, such as short acting hyoscyamine, may be taken. Parents should be told that such medication may help a lot, only a little, or not at all. They should not view the medication as a “cure” or expect it to “work” immediately or completely. If an hour has passed and, despite these measures, the pain is the same or worse, the doctor should be called.
Effective Reassurance
How can the clinician discover parents’ unstated worries? They may have unacknowledged, irrational or displaced fears which, if not brought to light, may cause them to seek yet another “second opinion” and more diagnostic intervention. An open ear can discern clues during history taking—clues that may seem to be unimportant statements about events and experiences that were actually deeply painful, such as a parent who experienced frightening surgery during childhood, or the loss of sibling or parent, or whose favorite aunt developed abdominal pain, was told by her doctor that it was nothing to worry about, but then turned out to have colon cancer. Once these emotional burdens are uncovered, they may be easily relieved by, for example, the information that colon cancer is extremely rare in children.
The moment reassurance takes hold is signaled by a perceptible change in the parents’ mood from frustration and worry to relief. The value of effective reassurance is that it enables them to once again expect their child to cope with symptoms and the tasks of growing up.
Continuity and Accessibility of Care
If an hour has passed and, despite the initial measures, the pain is the same or worse, parents fear that a serious cause of abdominal pain may have supervened, such as appendicitis, or that something serious had been missed and is now declaring itself. It behooves the physician to share these concerns about an unusually severe and prolonged bout of pain and respond with prompt reassessment of the child’s condition.
Psychosocial Aspects of Clinical Management
If all American children with RAPS consulted pediatric gastroenterologists one time within 1 year, then each physician would have to see an estimated 30 RAP patients per day, 250 days per year. The implausibility of his scenario begs the question: what prompts a referral to a sub-specialist for evaluation of this functional disorder? [10, 11]
I reviewed the psychosocial histories of 50 of my recurrent abdominal pain patients, selected at random, and was somewhat surprised to find that, in 44 of them, the consultations were prompted by new or increased concerns about symptoms that had been present and less problematic long before the current exacerbation. It is not accurate or helpful to label RAPS as a psychogenic disorder (i.e., “due to psychic, mental or emotional factors and not to detectable organic or somatic factors” [12]). However, if the goal of the clinician extends beyond merely diagnosing and prescribing for the presenting complaints, but also includes getting at the origins of the complaints and what prompted the referral, then that understanding is achieved by bringing the psychosocial elements of the illness to light. It takes an investment of the clinician’s time because, as the documentarian Ken Burns has said, “Meaning accrues in some sort of duration.” Grasping the meaning of a patient’s illness empowers the clinician to help the patient overcome it.
Examples
A 9-year-old’s abdominal pain complaints became more noticeable when her maternal grandfather was diagnosed with lung cancer. Her mother became preoccupied with her terminally ill father and the patient was cared for by a neighbor much of the time. Abdominal pain complaints emerged during the child’s unspoken loneliness for her mother who had become less emotionally available to her during her grandfather’s health crisis
The parents of a 13-year-old girl argued frequently. Eighteen months prior to the consultative visit, the week of the Challenger explosion, the patient developed acute abdominal pain while her mother was away from home on a 10-day business trip. The patient was hospitalized and her pains were determined to be of a non-surgical nature. Her complaints subsided after she was discharged to home. However, her pains then flared; episodes lasting hours recurred daily, but never woke her from sleep. The deterioration in her abdominal pain complaints coincided with a family crisis caused by the discovery of her older brother’s stealing and substance abuse behavior.
A 12-year-old worry-prone, perfectionistic boy had long complained of occasional stomach aches relieved by bowel movements. His parents’ marital relationship was contentious, but stable. “We’ve been married for nineteen years and two weeks and we’ve fought for nineteen years,” the mother said. It turned out that 5 months prior to the consultation, his friend’s parents divorced. Two months prior to the consultation, the patient’s family suffered financial difficulties. The severity and frequency of his abdominal complaints intensified and he experienced bouts of dyspnea. Their family physician diagnosed the cause of his dyspnea to be emotional distress. He advised the parents to clarify to their son that they had no intention of divorcing. The patient seemed relieved upon hearing this and his bouts of dyspnea improved. However, there were still worries about his recurrent abdominal pains. His abdominal pain complaints improved after a diagnosis of the Recurrent Abdominal Pain Syndrome and its safety and positive outlook for improvement were explained.
It is likely that physicians are seldom consulted for most children with recurrent stomach aches; they are effectively managed without having to be referred to a pediatric sub-specialist [11]. What motivates those who are referred? They are referred because they are perceived by parents, pediatricians or both as having symptoms that are especially acute, incapacitating, refractory to first-line management and are therefore more worrisome. It turns out that, in most such patients, the perceived acuity of the child’s symptoms, i.e., the factor that makes the symptoms require urgent attention now, not later, is not just the abdominal pain per se, but the fear created by unrecognized emotional distress caused by recent or remote events in the lives of family members, particularly the parents, in whom the child’s sense of secure stability resides [10, 13].
The more comprehensive biopsychosocial method of evaluating a child referred for RAPS requires 1½–3 h of time for the initial consultation. Is this an indulgent waste of time? The following case exemplifies how comprehensive evaluations employing this model of clinical practice can resolve what I’ll refer to as a functional abdominal pain crisis.
Arnold, 8 years old, complained continuously of abdominal pains and hadn’t been to school in 2 weeks. Seven weeks prior to the consultation, he had a 3 day systemic febrile illness with temperatures as high as 104 °F. Abdominal pain began on the second day of his illness, prompting an Emergency Room visit. An abdominal CT scan revealed “slightly enlarged appendix and mesenteric lymph nodes.” He was hospitalized overnight for observation. The next day, his fever, abdominal pain, and white blood count had diminished and he was discharged to home with a diagnosis of systemic viral illness.
He awoke at 3 AM with increased abdominal pain and was taken to another Emergency Room where a second abdominal CT scan showed no change. A diagnosis of a viral illness was again given. The parents were told that the pain would resolve in 1 or 2 weeks.
Continued bouts of pain lasting 10–40 min often doubled him over, and occasionally woke him between 3 and 4 AM. Abdominal radiographs, urinalysis, and stool specimens for O & P were negative. The patient was evaluated by a pediatric gastroenterologist twice during the next week. A diagnosis of mesenteric lymphadenitis was made. Acetaminophen alternating with Ibuprofen were prescribed but failed to help.
The night prior to my consultation, the abdominal pain became worse. In addition, the patient complained of pain in his sternum and neck. He pleaded with his parents for relief. “I’ll even take a shot! Just make it stop!”
I saw the patient on an urgent basis the next morning. The review of systems revealed that he had become reluctant to eat his favorite foods and ate less than his usual portions, but had not lost weight. He had been afebrile since the third day of his initial febrile illness. He was “very energetic, even hyperactive” except during his pains. His stool pattern was unchanged (1–2 per day, of varying consistency). “He suffered leg aches all his life.” His father, who had Juvenile Rheumatoid Arthritis as a child and still suffered joint aches, massaged his son’s legs at bed time every evening.
Past history revealed no hospitalizations or serious illnesses prior to his present illness.
Family history: There was an unusual burden of illness and disease in family members. The patient’s mother had 3 weeks of continuous vomiting of obscure origin at the time she entered grade school. She was abused at 8 years of age and had recurrent panic attacks since then. She experienced episodes of blindness, vertigo and tinnitus while in middle school. She had dermatologic changes diagnosed as Reynaud’s Disease in adolescence and was told that she would probably develop Lupus. Lupus had not emerged during the ensuing 22 years, “…but now, every time I get sick, my mom worries about Lupus.” She had her gallbladder removed 2 years previously. A hysterectomy was done for severe metrorrhagia. She had two hospitalizations for Meningitis, at 22 and 32 years of age (when the patient was 4 years old). When I asked her to characterize her health, she answered, “I have always been sick, especially with things doctors couldn’t diagnose…no matter what I do, I am not healthy. I’m just not a healthy person.”
The maternal grandfather had been totally disabled since an industrial accident that occurred 4 years prior to the mother’s birth. The maternal grandmother suffered sudden bouts of globus, swelling of her limbs, and near-syncope. The patient’s father had been a sickly child and, as an adult, had frequent pains in his back and ankles. The paternal grandfather died at 55 of abdominal cancer, when the patient’s father was 21 years of age. The paternal grandmother was currently hospitalized for severe inflammatory bowel disease. At 21 months of age, the patient, his mother and maternal grandmother were in a motor vehicle accident. The patient witnessed his mother being placed on a trauma board, put into an ambulance and driven away.< div class='tao-gold-member'>Only gold members can continue reading. Log In or Register a > to continue