Fatty liver and nonalcoholic steatohepatitis

Chapter 7 Fatty liver and nonalcoholic steatohepatitis




Key Points













Pathogenesis


NASH is thought to be a disease of lipotoxic injury to hepatocytes caused by nontriglyceride metabolites of free fatty acids. Triglyceride in the lipid droplets may actually be a protective response to store fatty acids in an inert form. The specific metabolites of free fatty acids that cause lipotoxic injury have not been fully identified. Possibilities include ceramides, diacylglycerols, lysophosphatidyl choline species, and phosphatidic acid species.


The causes of hepatic lipotoxicity are attributable to one or more of the following abnormalities in the trafficking of fatty acids in the body:







Clinical Features




Jun 4, 2016 | Posted by in GASTROENTEROLOGY | Comments Off on Fatty liver and nonalcoholic steatohepatitis
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