Ethical Issues in Hemodialysis



Fig. 8.1
Dr. Belding Scribner discusses the evolution of hemodialysis with Dr. McCormick at the University of Washington



This arteriovenous shunt was made on the morning of March 9, 1960 (Fig. 8.2), and shortly thereafter installed at the wrist of the patient, Clyde Shields, a machinist, by a University of Washington surgeon, David Dillard, MD. That same afternoon, Clyde had his first hemodialysis session using the arteriovenous shunt as the access point to his circulatory system (Fig. 8.3). It worked. After the hemodialysis session, the loop was closed to allow normal circulation of blood. The shunt would provide access for all future hemodialysis sessions. A door had opened. For the first time, there was hope for patients with chronic renal failure. Clyde was able to return to his work as a machinist at an engineering company that provided work for the Boeing plant. He lived an additional 11 years following his initial treatment. He died, not from kidney failure, but from a myocardial infarction. During those years, Scribner’s work continued, and the shunt was constantly improved by new innovations. Clyde Shields, the first long-term survivor, benefitted from these new and improved shunts during that time.

A326551_1_En_8_Fig2_HTML.jpg


Fig. 8.2
Top panel: the Teflon arteriovenous shunt made of two thin-walled Teflon cannulas with tapered ends designed for long-term use in patients with “chronic renal failure.” Bottom Panel: the Teflon shunt after implantation. Long Teflon arms and long subcutaneous tunnels were used to decrease the risk of infection. The shunt is attached to a “Swagelok® connector,” a stainless-steel arm plate covered with a plastic protective cover. The arm plate anchors the cannulas to the arm and provides the means for easily changing the external circuit from bypass to dialyzer circuit. The rate of blood flow in this assembly is 100–200 ml. Patency of the blood artery and vein between dialysis sessions is maintained via an external arteriovenous fistula created by means of a Teflon-Silastic loop (Images used with permission from the Northwest Kidney Centers, Seattle, WA)


A326551_1_En_8_Fig3_HTML.jpg


Fig. 8.3
Clyde Shields, Scribner’s first patient to use the arteriovenous shunt. Note the Skeggs-Leonards dialyzers and the chest-type freezer behind Clyde and the heparin pump borrowed from the Physiology department (Images used with permission from the Northwest Kidney Centers, Seattle, WA)



Seattle’s Artificial Kidney Program


When it became clear that Mr. Shields was surviving because of the dialysis treatment, other patients were enrolled. Mr. Harvey Gentry was the next patient enrolled followed by Mr. Rollin Heming and in July 1960, Mr. Jack Capelloto. All were suffering from end-stage renal disease (ESRD), and all received hemodialysis at the University of Washington in Seattle. Scribner recounted his desire to admit additional patients to hemodialysis after the first four patients demonstrated that hemodialysis was effective. However, UW Hospital medical director, John Hogness, refused his request. Hogness believed that once a patient was admitted to chronic hemodialysis, there was an implicit moral imperative that the treatment should continue as long as needed. Hogness knew the university did not have the funds to provide this and felt that from an ethical standpoint, it was not possible to expand the university’s program without a guarantee of funding. He encouraged continuing research aimed at improving this treatment regimen. The success in treating these early patients with chronic renal failure was at first a closely guarded secret out of fear that overwhelming numbers of patients with end-stage renal disease (ESRD) would apply for hemodialysis, once it was discovered to be efficacious and before necessary provisions had been made.

Dr. Scribner described late-night seminars in his hotel room at the annual American Society for Artificial Internal Organs (ASAIO) meeting in Atlantic City, 1960. He and Quentin demonstrated to nine nephrologists the art of “tube bending” so they could return home, make their own cannulas, and enroll their ESRD patients in hemodialysis programs in cities across the country. Scribner actually brought Mr. Shields to Atlantic City as a living demonstration of the month-long success of his treatment. Dr. Shreiner, president of ASAIO, allowed a brief paper written by Scribner describing his technique in chronic hemodialysis to be published in the report on the ASAIO meeting, even though Scribner had not been on the program due to the late breaking nature of his discovery. Gradually, as word spread, nephrologists and nurses from throughout the USA flocked to Seattle, WA, to learn about hemodialysis.

Scribner recognized the financial problems in expanding the hemodialysis program at the University of Washington. Once a patient was accepted for dialysis, the patient would need treatment three times per week for the rest of his/her life. How was such treatment to be paid for? Scribner, with the support of the dean of the medical school, Dr. George Aagaard (1954–1964), appealed for assistance from the community. Dr. James W. Haviland, then president of the King County Medical Society, responded to Scribner’s request for community support. He assisted through donations and a grant from the Hartford Foundation in establishing the world’s first hemodialysis center. On January 1, 1962, the Seattle Artificial Kidney Center (SAKC) opened in the former nurses’ quarters in the basement of Swedish Hospital. It was a nonprofit organization dedicated to the care of hemodialysis patients. The SAKC was a novel operation at the time as the task of hemodialysis was turned over to the nurses. Scribner never sought a patent on his invention as his goal was to keep the costs down and to provide hemodialysis for all who need it. Seattle became a leader in teaching patients and their families the methods of “home dialysis.” This was more convenient for patients and more cost-effective. Dr. Christopher Blagg, a colleague with Scribner in the Division of Nephrology from 1963, became executive director of the newly renamed Northwest Kidney Centers from 1971 until 1998, a period of amazing growth in the treatment of dialysis patients [3].


The Ethics of Access


Bioethical issues were inherent in this new hemodialysis program. Chronic hemodialysis marked the beginning of an era in which machines could supplant the functions of human organs. Such machines were in limited supply. In 1960, there were only three hemodialysis machines in Seattle, so only a few patients could be accommodated for ongoing hemodialysis, raising the questions: Who should live when not all can live? What criteria should be used in selecting patients? The Seattle physicians attending to the hemodialysis patients felt they could determine who was medically eligible, but should not have the responsibility for choosing among competing candidates. They appealed to the King County Medical Society for assistance. This led to the formation of an anonymous body of seven volunteer citizens who formed the Admissions and Policies Committee of the Seattle Artificial Kidney Center at Swedish Hospital. They had no special training and were given no guiding principles. They were to rely upon their own moral intuition. They were given a few exclusionary points. Children were to be excluded due to the many unknown aspects of the effects of hemodialysis on a growing child. Persons over 45 years of age were to be excluded as they were more likely to experience other comorbidities. Only citizens of the state of Washington could be included, as the university was a public university and supported by state tax dollars.

Only gold members can continue reading. Log In or Register to continue

Stay updated, free articles. Join our Telegram channel

Jul 25, 2017 | Posted by in NEPHROLOGY | Comments Off on Ethical Issues in Hemodialysis

Full access? Get Clinical Tree

Get Clinical Tree app for offline access