Author
Year
Study origin
Study design
N. Pts
Side recurrence
Stent type
TS %
CS %
Major complications stent related %
Mortality stent related %
De Palma et al. [11]
1998
Italy
PS
16
Esophagogastric A.
Plastic stent
81.2
100
23
6.2
Esophagojejunal A.
Ultraflex stent
Microvasive stent
Watertown stent
Mass stent
Yates et al. [13]
1998
USA
PS
11
Gastroduodenal A.
Wallstent (biliary and tracheobronchial)
91
82
0
0
Gastrojejunal A.
Endocoil
Duodenum Jejunum
Ultraflex stent
Lee et al. [14]
2001
Korea
RS
11
Gastrojejunal A.
Duodenum Jejunum A.
87
82
0
0
Gastroduodenal A.
Song stent
Siersemaet al. [15]
2001
The Netherlands
RS
31
Cervical esophagogastric A.
Covered Gianturco Z stent
90.3
100
19.3
0
Esophagojejunal A.
Partially covered Flamingo Wallstent
Partially covered Ultraflex stent
Jeong et al. [4]
2004
Korea
RS
25
Gastrojejunal A.
Choo stent
96
100
20
0
Esophagojejunal A.
Niti-S stent
Song stent
O’Connor et al. [12]
2004
Ireland
CR
2
Gastrojejunal A.
Wallstent
100
100
0
0
Solt et al. [24]
2004
Hungary
CR
2
Gastrojejunal A.
Boubella FerX-ELLA
100
100
0
0
Esophagojejunal A.
Naso et al. [21]
2005
Italy
CR
3
Esophagojejunal A.
Esophacoil
100
100
0
0
Perez-Roldan et al. [16]
2006
Spain
CR
3
Esophagoenteral A.
Ultraflex stent
100
100
0
0
Song et al. [5]
2007
South Korea
RS
20
Gastrojejunal A.
Niti-S stent covered
100
80 uncovered
0
0
Esophagojejunal A.
Niti-S stent uncovered
100 covered
Yang et al. [19]
2007
South Korea
RS
16
Gastroduodenal A.
FC retrievable stent
81
100
19
0
Covered dual stent
Kim et al. [23]
2007
South Korea
RS
32
Esophagojejunal A.
FC retrievable stent
94
91
31.2
0
Covered dual stent
Song et al. [18]
2007
South Korea
RS
39
Gastrojejunal A.
Song FC stent
100
90
25.6
5.1
FC retrievable stent
Bare nitinol stent
Dual stent
Cho et al. [20]
2009
South Korea
RS
20
Esophagojejunal A
Niti-S stent
100
70
30
0
Gastroduodenal A.
Choo stent
Gastrojejunal A.
Kim et al. [17]
2009
South Korea
RS
47
Esophagojejunal A.
Niti-S stent (covered/uncovered)
95.7
87.2
27.6
0
Gastrojejunal A.
Choo stent (covered/uncovered)
Tong et al. [7]
2010
China
PR
35
Esophagojejunal A.
Ultraflex stent
97.6
100
14
0
Esophageal remnant
Choo stent
GOO
Niti-S stent
Extrinsic compression ERF
Kim et al. [22]
2011
South Korea
RS
35
Esophagojejunal A.
Choo esophageal stent
92 of 39
90 of 39
44 of 39
0
39 stent
Gastroduodenal A.
Hanaro esophageal stent
Gastrojejunal A.
Niti-S esophageal, pyloric/duodenal stent
Wallstent colonic stent
WallFlex duodenal stent
In these patients, stent placement may be more difficult due to anatomic alteration resulting from surgery, and sometimes functional results are disappointing [17, 18].
An accurate endoscopic and radiologic evaluation is mandatory before stent placement in order to know the type of surgical procedure performed.
The lack of symptomatic improvement after stent insertion may be due to multiple bowel strictures or ileus as a result of peritoneal seeding [4, 17, 18].
Multiple strictures occur in 11 % of cases, and stent placement for two successive synchronous strictures is exceptional [13].
SEMS insertion may be performed both by endoscopically guided and by fluoroscopically guided methods. Similar high technical success (TS) and clinical success (CS) rates have been reported (92 and 90 % TS and CS, respectively, in endoscopic approach vs TS at 94–100 % and CS at 90–96 % in fluoroscopic approach) [4, 5, 22, 23].
However, the advantages of the endoscopic method in patients with distal gastrectomy are the ease of accessing the stricture site and the avoidance of looping the delivery system through the dilated gastric lumen due to the stiffness of the endoscope [20].
The friction between the working channel of the endoscope and the long delivery system may result in a difficult stent insertion when the endoscope is in an angulated position [22, 25]. Balloon dilatation can be exceptionally performed when the tightness of strictures does not allow the introduction of the delivery system; excessive dilatation should be avoided to prevent stent migration [24].
A stent at least 2–4 cm longer than the stricture should be chosen to allow for a 1–2 cm extension beyond the proximal as well as distal tumor margins [15].
Generally, in patients treated with SEMS, dysphagia is relieved in approximately 90 % of cases, and these patients undergo significantly fewer procedures, thus spending fewer days in the hospital [26, 27].
Stent placement has several advantages over surgery: it is a less-invasive procedure is preferred both by the patient and surgeon because of its lower morbidity, shorter procedural time and hospital stay, as well as faster recovery of gut function [17, 18, 28].
This is important for patients whose life expectancy is of 4–6 months, or less.
The overall survival rate for stent-treated patients has been reported to be similar to that for patients undergoing surgery, whose hospitalization is three times longer and costs are three times greater [29].
The recurrent rate of stenosis in patients with SEMS placed for anastomotic malignant obstruction ranges from 8 to 46 % after an interval of 2–21 weeks. It is generally due to tumor in-overgrowth [5, 30].
Some studies report that early occlusion of SEMS (within 4 weeks after their implantation) occurs more frequently in patients with the stent at the anastomotic level, than in those treated for unresectable cancer, but the causes are unknown [5, 6, 31].
Chemotherapy could decrease the tumor ingrowth and overgrowth; however, chemotherapy after stent placement is likely to shrink the tumor, increasing stent migration, if a covered SEMS has been used [5, 19, 32].
Stent migration rates range from 4.2 to 27.8 %; a pooled analysis of 21 studies reports that migration rate was 2.7 and 16 % for uncovered and covered stents, respectively [33].
An appropriate choice among the marketed SEMS according to the type of surgery performed may reduce the migration rate of stents placed in malignant recurrences [17].
A retrospective study reported that a double coaxial stent had a longer patency and lower migration rate than an uncovered stent in anastomotic recurrence [5].
At present, several types of SEMS are available, varying by type of alloy, configuration, degree of shortening after their release, lengths and diameters, presence, type, and extent of covering, delivery system, expandable force, presence or absence of anti-reflux valve, and removability.
Most SEMS are made of nitinol, an alloy of nickel and titanium, whose peculiarity is super-elasticity and shape memory.
The covering is either polyurethane, silicone, or polytetrafluoroethylene (PTFE). Their flexibility, the small diameter of the delivery system, and the large availability of models allow the treatment of any type of malignant obstruction [26, 34].
There are no data to date demonstrating significant differences in outcomes or complications among SEMS types. Therefore, the choice of specific SEMS is often based on the endoscopist’s experience, although the initial stent selection has a significant impact on the clinical outcome in patients with inoperable malignancy [35].
Use of a self-expandable plastic stent (Polyflex® stent, Boston Scientific, Natick, MA, USA) is not recommended in GI anastomotic malignant recurrence. The major disadvantage of the current version of plastic stents is the large diameter and stiffness of the stent delivery system when compared with metal stents. Therefore, plastic stents cannot be released in patients with angulated strictures as in anastomotic ones.
SEMS may be placed hardly in some cases, especially in the presence of narrow bowel loops. In such situations, SEMS cannot fully expand, and they may migrate or cause perforation due to excessive stretching of gut wall, determined by the device. New D-Weave Niti-S colonic stent (TaeWoong Medical Co., Seoul, South Korea) has characteristics that may reduce the risk of such complications. It is a self-expandable nitinol stent, whose particular configuration confers some interesting properties to the device, such as compliant flexibility, high expansible force, and negligible foreshortening, in order to reduce the risk of migration, perforation, and inadequate expansion [36].
SEMS for malignant anastomotic obstruction after:
Esophagectomy
For patients with a gastric tube interposition after esophagectomy, recurrent tumor growth occurs at the level of cervical anastomosis [37].
Endoscopic placement of a stent for lesions within a few centimeters of the upper esophageal sphincter (UES ) is challenging. Complications such as migration, perforation, and tracheal compression can occur. The opening of the upper flared end of a regular esophageal SEMS is often incomplete and causes an intolerable foreign body sensation, leading to an inadequate swallowing capacity [15, 38, 39].
The use of SEMS with a diameter <18 mm could minimize patient intolerance and stent-related complications [15, 39].
The risk of distal migration of the stent is high as the length of the anastomotic stricture is short, preventing an adequate adhesion. In fact, even placing a 6-cm stent, most of it is free into the stomach.
Siersema et al. inserted 4 covered Gianturco Z stents, (body diameter/flared ends: 18–25 mm) and 6 partially covered Ultraflex stents (body/flared ends diameter: 18–23 mm) in 10 patients with a recurrent tumor located in the proximal part of the gastric tube interposition. They obtained technical success rate of 90 %, improvement of dysphagia of at least 1 grade, and complications and recurrent dysphagia due to tumor overgrowth in 30 and 20 % of patients, respectively [15].
In selected cases, as in the one mentioned above, anatomic morphology may prevent the use of SEMS. The only palliative option we use is thermal ablation with APC or neodymium: yttrium–aluminum–garnet (Nd:YAG) laser.
Small diameters SEMS (12, 14, 16 mm the body; 14, 16, 18 mm the upper flared end) may be used in patients with neoplastic recurrence occurring after chemo/radiation treatment and surgery, for laryngeal cancer.
Montgomery salivary bypass tube (MSBT) (Boston Medical Products, Westborough, USA) may also be used as a palliative measure in this subgroup of patients.
MSBT is a silicone prosthesis with a flared upper end. It is available in 7 sizes, ranging 8–20 mm. The length of the stent is 191 mm.
It can be placed trough the stricture using a Savary-Gilliard dilator. The stent is released with a finger, inserted deep in the throat, when the dilator is partially retracted. This maneuver allows the mobilization of the MSBT. The final adjustment is made pushing gently the stent with the Savary and, in the end, with the tip of the scope.
However, its upper flared end has a large diameter, and it should be adapted according to the modified anatomic morphology, by cutting it with scissors before its introduction [40–42].
The onset of an esophagorespiratory fistula (ERF) is an ominous complication that can occur both in patients with esophageal cancer and also in those who underwent previous surgery. ERF can be successfully sealed by using of covered SEMS. Late erosion into the trachea may be a stent placement complication; however, it should be kept in mind that these patients have a short life expectancy (usually less than 3 months) [43].
Esophageal Resection
After lower third esophageal resection, the placement of a stent across the esophagogastric anastomosis has an increased chance of migration because of the relatively more spacious stomach into which the distal end of the SEMS projects freely [35].
The use of a large bore covered stent has been suggested in order to avoid both ingrowth and migration [7, 44].
Flexible stents are preferred for angulated strictures to prevent that the ends of the prosthesis from assuming an eccentric position into the lumen leading to pressure necrosis, ulceration, bleeding, perforation, and esophagoaortic fistula [25].
In these cases, the new conformable stents by TaeWoong (BETA TM Stent, TaeWoong Medical Co., Korea) might represent a useful solution. This is a prototype of a conformable SEMS able to fit into angulated or tortuous strictures, thus avoiding the risk of pressure necrosis. Fully covered design allows reposition or removal of the device. Two additional covered mesh (double layer) should prevent migration. However, studies are ongoing in order to evaluate their safety and efficacy (Fig. 12.1).