Endoscopic bariatric therapy consists of devices or procedures for primary weight loss or weight regain after Roux-en-Y gastric bypass that are placed or done endoscopically. In most cases, they result in less weight loss, but fewer complications than bariatric surgery; and more weight loss than lifestyle therapy or weight loss medications. These therapies are important advances to treat patients with obesity. This article focuses on therapies or devices with US Food and Drug Administration approval or those with current or planned US pivotal trials.
Key points
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Multiple devices and procedures for primary treatment of obesity and treatment of weight regain after Roux-en-Y gastric bypass (RYGB) are now available.
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In many cases, efficacy of these procedures and devices has been demonstrated with randomized sham-controlled or nonsham-controlled trials.
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Multiple gastric and small bowel devices for weight loss are currently being evaluated or have US pivotal trials planned for US Food and Drug Administration approval.
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Endoscopic revision of the gastrojejunostomy for weight regain after RYGB is an effective treatment for weight regain as shown in a randomized sham-controlled trial for patients with dilation of the gastrojejunostomy.