Diverticular Disease




Pericolic abscess or phlegmon


Pelvic, intra-abdominal, or retroperitoneal abscess


Generalized purulent peritonitis


Generalized fecal peritonitis

Table 17.2
Hansen and Stock classification [19]






Acute uncomplicated diverticulitis


Complicated diverticulitis


Peridiverticulitis, phlegmonous diverticulitis


Abscess diverticulitis, covered perforation, fistulation


Free perforation


Chronic recurrent diverticulitis

Table 17.3
Ambrosetti et al. classification [20]


CT findings

Moderate diverticulitis

Localized sigmoid wall thickening (<5 mm), pericolic fat stranding

Severe diverticulitis

Abscess, extraluminal air, extraluminal contrast

Unfortunately, these different classifications of diverticular disease have led to conflicting terminology in the current literature. Moreover, none of the classifications seem to sufficiently embrace the entire spectrum of the clinical presentation of the disease. A new classification of sigmoid diverticulitis corresponding to the German guidelines for diverticular disease classification (GGDDC) [17] (Table 17.4) was proposed at the end of 2013. This modern classification seems to form a sound basis for developing appropriate strategies to evaluate differentiated treatment.

Table 17.4
German guidelines diverticular disease classification



Typ 0

Asymptomatic diverticulosis

Typ 1

Uncomplicated diverticulitis

 Typ 1a

Diverticulitis without peridiverticulitis

 Typ 1b

Diverticulitis with phlegmone

Typ 2

Complicated diverticulitis

 Typ 2a

Microabscess (<1 cm)

 Typ 2b


 Typ 2c1

Purulent peritonitis

 Typ 2c2

Fecal peritonitis

Typ 3

Chronic diverticular disease

 Typ 3a

Symptomatic uncomplicated diverticular disease

 Typ 3b

Recurrent diverticulitis without complications

 Typ 3c

Recurrent diverticulitis with complications (stenosis, fistula)

Typ 4

Diverticular hemorrhage

17.3.1 Asymptomatic Diverticulosis

Asymptomatic diverticular disease is frequently an incidental finding during the assessment of a patient for other reasons, such as routine screening for colon cancer. No treatment or follow-up needs to be offered to this large population.

17.3.2 Uncomplicated Diverticulitis

Acute diverticulitis is usually associated with signs and symptoms of active inflammation. Patients present with abdominal pain in the left lower quadrant or suprapubic region. Pain is generally exacerbated by eating and diminished upon defecation or the release of flatus, which suggests colonic wall tension caused by higher-than-normal intraluminal pressure. Assessment can indicate fullness or mild tenderness in the left lower quadrant. Laboratory findings show increased infection values (C-reactive protein, leukocytes). The morphologic correlate CT is bowel wall thickening (Fig. 17.1) or inflammatory infiltration of pericolic fat (Fig. 17.2). Patients with uncomplicated diverticulitis can usually be treated conservatively. Few patients develop subsequent attacks or complications that necessitate surgery [21, 22].


Fig. 17.1
Uncomplicated diverticulitis: bowel wall thickening (→)


Fig. 17.2
Peridiverticulitis/Phlegmon (→)

17.3.3 Complicated Diverticulitis

In addition to the symptoms of uncomplicated diverticulitis, flank rebound or guarding may be detectable in patients with complicated diverticulitis. Generalized tenderness suggests a free colon perforation and peritonitis. Bacteria may breach the mucosa and extend the process through the full wall thickness, ultimately leading to perforation. The extent and localization of the perforation establish its clinical course. Microperforations can remain contained by pericolic fat and mesentery and may cause small pericolic abscesses. Large perforations can result in an extensive abscess, which could continue around the bowel wall and form a large inflammatory mass or extend to other organs. Free perforation into the peritoneum, causing frank peritonitis, can be life-threatening, but it is rare. The morphologic correlates on CT are mesocolic or retroperitoneal abscess (Fig. 17.3) or an abscess in the minor pelvis, or free air (Fig. 17.4) and/or fluid. Complicated diverticulitis usually requires elective surgical intervention. Patients who present with diffuse peritonitis or free perforation require emergency surgery.


Fig. 17.3
Complicated diverticulitis with abscess (→)


Fig. 17.4
Complicated diverticulitis with perforation (free air →)

17.3.4 Chronic Diverticular Disease

The clinical presentation of recurrent diverticular disease varies between mild and severe symptoms. The typical sign of chronic inflammation on CT is bowel wall thickening, sometimes with colonic stenoses or fistulas. However, multiple episodes of diverticulitis are not associated with increased mortality or an increased risk of complicated diverticulitis [2123]. The potential risk of free perforation decreases with each previous episode of diverticulitis [23]. Therefore, recommending colectomy after the first episode of complicated diverticulitis is not justifiable based solely on the potential risk of free perforation. Greater consideration should be given to the clinical course, symptoms (e.g., pain), the risk of recurrence, and the patient’s basic risk. The indications for operative intervention should be determined individually and with reference to the patient’s respective characteristics (age, general condition, and number/frequency of episodes of diverticulitis). In the case of recurrent diverticulitis with complications, such as stenoses (Fig. 17.5) or fistulas (Fig. 17.6), a surgical treatment is usually necessary.


Fig. 17.5
Chronic recurrent diverticulitis with stenosis


Fig. 17.6
Chronic recurrent diverticulitis with colovesical fistula

17.3.5 Diverticular Hemorrhage

Important lower gastrointestinal bleeding can be caused by diverticula, vascular ectasias, colitis, or neoplasms [2426]. Diverticular sources have been reported to be the most typically identified cause, accounting for more than 40 % of lower gastrointestinal bleeding episodes [27, 28]. Severe hemorrhage can occur in 3–5 % of patients with diverticulosis [29, 30]. Despite the fact that most diverticula are in the left colon in individuals from Western countries, the site of bleeding may more often be located in the proximal colon [3134]. The clinical presentation of diverticular hemorrhage is usually one of an abrupt, painless onset. Hemorrhage ceases spontaneously in 70–80 % of patients, and rebleeding rates range from 22 to 38 % [29, 30]. The chance of a third bleeding episode can be as high as 50 %, resulting in the frequent recommendation of surgical resection after a second bleeding episode [35]. The recommended initial diagnostic test is colonoscopy. If the bleeding source is identified by colonoscopy, endoscopic therapeutic maneuvers can be performed. If the bleeding source is not identified, further assessment with noninvasive (nuclear scintigraphy) or invasive (angiography) techniques can be undertaken in an attempt to localize and treat the bleeding source. Surgery in lower gastrointestinal bleeding is usually reserved until endoscopic or angiographic treatments fail. Segmental resection is most usually considered if the bleeding site is clearly identified from a therapeutically unsuccessful angiographic or endoscopic procedure. Subtotal colectomy may be required in patients with persistent bleeding and no angiographic or endoscopic identification of a definite bleeding site.

  • Diverticular disease can be classified as asymptomatic diverticulosis, uncomplicated diverticulitis, complicated diverticulitis, recurrent symptomatic disease, and diverticular hemorrhage.

  • Treatment recommendations include conservative approaches with observation and dietary modifications, as well as antibiotic treatment, abscess drainage, and surgery. A differentiated treatment depends on disease stage.

  • A new classification of sigmoid diverticulitis corresponding to the GGDDC seems to sufficiently embrace the entire spectrum of the clinical presentation of the disease.

17.4 Diagnostics

17.4.1 Radiological Imaging

Radiological imaging techniques that are used in the diagnosis of acute diverticulitis are soluble contrast enemas, ultrasound, CT, and magnetic resonance imaging (MRI). Today, soluble contrast enemas are obsolete for diagnosing acute diverticulitis because of their low accuracy and the inability to determine the extent and complications of diverticular disease. The primary disadvantage of contrast enema examination in the evaluation of diverticulitis is that the inflammatory process is predominantly extramucosal. Therefore a contrast enema is often unsuccessful in delineating complications of acute diverticulitis and may underestimate the extent of pericolonic disease. Finally, and perhaps most important, a contrast enema has absolutely no role in the therapeutic intervention for diverticulitis.

Ultrasound is a real-time dynamic examination with wide availability and easy accessibility. Similar to CT, ultrasound is capable of evaluating the transmural involvement of diverticular disease using a ,quick noninvasive technique that eliminates the need for intravenous or intraluminal contrast. In some European countries, ultrasound is routinely used as the initial imaging technique in patients clinically suspected of having acute colonic diverticulitis [36, 37]. However, the use of CT in the evaluation of patients with acute diverticular disease has greatly increased. CT has the advantage of delineating the extent of the extraluminal disease process, provides an unlimited view, and may also direct therapeutic intervention in the case of complicated disease (e.g., CT-guided percutaneous drainage of intra-abdominal abscesses).

The most widely used diagnostic criteria to determine acute diverticulitis with ultrasound and CT are increased thickness of the colonic wall, pericolic fat stranding, and the presence of inflamed diverticula. A high diagnostic sensitivity and specificity are reported for both ultrasound (92 and 90 %, respectively) and CT (94 and 99 %, respectively) [38, 39]. However, abdominal ultrasound is often limited by overlying gas that obscures the diseased segment and may produce false-negative results. This problem is accentuated by obesity and acute diverticulitis, where inflammation may cause a localized ileus in neighboring small-bowel segments. Disease in the distal sigmoid colon is also more difficult to assess because it can be poorly accessible to the ultrasound as a result of interference from the bladder and other pelvic structures. Its main limitation lies in the operator variability inherent in ultrasonography compared with CT, in which subjective interpretation is much less problematic.

MRI has the advantage that no ionizing radiation or intravenous contrast medium is needed to achieve a higher soft-tissue contrast than CT. MRI produces quality images with subtle details superior to those from both CT and ultrasound [40, 41]. MRI does not require the intravenous, oral, and rectal contrast necessary for optimal CT scans. In addition, MRI is not limited by poor visualization caused by overlying gas and fat. However, the high cost and current limited availability of MRI do not make it feasible for routine use at this time. Furthermore, MRI takes significantly longer than CT and may not be acceptable for use in critically ill patients [40, 41].

In conclusion, CT should be the standard radiologic imaging technique for diagnosing acute diverticulitis. CT may be substituted by ultrasound under favorable conditions.

17.4.2 Colonoscopy

Colonoscopy is not recommended in the acute phase to diagnose acute diverticulitis because of the potential risk of converting a sealed perforation to a free perforation by insufflation of air [42, 43]. Colonoscopy should usually be done 4–6 weeks after an episode of acute diverticulitis in order to exclude a colonic malignancy.

  • CT of the abdomen and pelvis is the most appropriate initial imaging modality in the assessment of suspected diverticulitis. It may be substituted by ultrasound under favorable conditions.

  • Colonoscopy is not recommended in the acute phase to diagnose acute diverticulitis because of the potential risk of converting a sealed perforation to a free perforation by insufflation of air.

17.5 Treatment

Treatment recommendations include conservative approaches with observation and dietary modifications, as well as antibiotic treatment, abscess drainage, and surgery [17]. However, scientific evidence is scarce for some aspects of diverticulitis treatment, leading to treatment often being guided by a surgeon’s personal preference. Many guidelines for the treatment of diverticular disease were developed to expand the evidence base for treatment, but no general guidelines exist. In addition to the above-mentioned GGDDC from 2013 [44], the 2014 practice parameters for the treatment of sigmoid diverticulitis from the American Society of Colon and Rectal Surgeons [45] should also be mentioned as recent guidelines. Their purpose is to provide information that decisions can be based on, rather than dictate a specific form of treatment. These guidelines should not be deemed inclusive of all proper methods of care or exclusive of methods of care reasonably directed to obtaining the same results. The ultimate judgment regarding the propriety of any specific procedure must be made by the physician in light of all the circumstances of the individual patient.

17.5.1 Medical Treatment

In the absence of complications and systemic signs and symptoms, patients with mild abdominal tenderness may be treated conservatively. Conservative treatment typically includes dietary modification and oral or intravenous antibiotics. This has been shown to be successful in 70–100 % of patients [46]. Uncomplicated diverticulitis may be managed in the outpatient setting with dietary modification and oral antibiotics for those without fever, excessive vomiting, or marked peritonitis, as long as follow-up is ensured. If these conditions are not met or the patient fails to improve with outpatient therapy, hospital admission is required. Antibiotics should be selected based on appropriate coverage for gram-negative and anaerobic bacteria [47]. Conservative treatment resolves acute diverticulitis in 85 % of patients [15]. After recovery from the first episode, fiber intake prevents recurrence in more than 70 % of patients [48]. Immunosuppressed or immunocompromised patients are more likely to present with perforation and fail medical treatment [49]. Approximately 15 % of patients develop pericolonic or intramesenteric abscess [50]. Abscesses smaller than 2 cm in diameter may resolve with antibiotic treatment without any further intervention, whereas larger abscesses may require percutaneous drainage. This may prevent an emergency operation and multistaged surgeries involving the creation and closure of a stoma [50].

17.5.2 Surgical Treatment

Surgical treatment of the disease can be emergent or elective, depending on the stage of the disease and the clinical presentation. Intraoperative surgical options are based on the patient’s status and the severity of intra-abdominal contamination [18] (Table 17.1). The desired surgical option is resection of the diseased segment with primary anastomosis, with or without intraoperative lavage or resection, and anastomosis with a temporary diverting ileostomy. In advanced stages of peritonitis, the Hartmann procedure (sigmoid colectomy, end colostomy, and closure of the rectal stump) is often performed, but it has been shown that the closure operation (Hartmann reversal) is not only technically challenging but also may be associated with significant postoperative morbidity and mortality [51]. Therefore, in an emergency situation because of free perforation, a primary anastomosis with a defunctioning ileostomy should be favored because the stoma reversal rate after primary anastomosis is higher than after the Hartmann procedure. The Hartmann procedure should be reserved for patients with perforated diverticulitis with severe septic complications. However, the final treatment decision – primary anastomosis or the Hartmann procedure – should depend on the patient’s situation. It is also important that the decision be based not only on intraoperative findings or the extent of peritonitis, but rather on the patient’s overall condition. Anastomotic healing may not occur in an unfit patient, even with mild inflammation, whereas patients with no or few comorbidities may fare well with primary anastomosis despite severe peritonitis [52].

A number of recent publications have discussed the use of laparoscopic peritoneal lavage and drainage for perforated sigmoid diverticulitis, as an alternative to resection [53, 54]. In the case of no localized diverticular bleeding, a subtotal colectomy should be performed if the diverticular bleeding site cannot be localized.

In this context, two prospective randomized studies from the Netherlands and Scandinavia are currently investigating the role of laparoscopic lavage with drainage for purulent and fecal peritonitis (Hinchey III and IV) compared with resection [55, 56]. Pending the results of these studies, laparoscopic lavage with drainage should be critically reviewed and subject to strict indications. According to the available datam the presence of fecal peritonitis or visible perforation is considered a contraindication for this procedure. Classical resection with abdominal lavage should also be performed if immunosuppression or septic disease is present.

The decision for elective colectomy after recovery from acute diverticulitis should be determined individually and with reference to the patient’s characteristics (age, general condition, severity of diverticulitis, and number/frequency of episodes of diverticulitis). In the case of recurrent diverticulitis with complications, such as stenoses or fistulas, surgical treatment is usually necessary.

There are several important points regarding surgical technique. From a technical standpoint, the proximal margin of resection should be in an area of pliable colon without hypertrophy or inflammation. Resection of the diseased colon along with removal of the entire thickened colonic segment is the desired goal. With respect to the extent of resection required, according to current data it is not necessary to remove the entire colonic segment bearing diverticula because such a strategy does not reduce the recurrence rate. The splenic flexure should be mobilized when necessary to perform adequate resection and anastomosis.

  • Depending on the severity of the inflammation, acute diverticulitis is treated conservatively or surgically.

  • Laparoscopic sigmoid resection with restoration of continuity has been the prevailing modality for treating acute and recurrent sigmoid diverticulitis.

  • The Hartmann procedure should be reserved for perforated diverticulitis with severe septic complications.

  • In the case of diverticular bleeding, a subtotal colectomy should be performed if the site of the diverticular bleeding cannot be localized.

17.6 Access

Laparoscopic sigmoid resection with restoration of continuity has been the prevailing modality for treating acute and recurrent sigmoid diverticulitis. The laparoscopic approach has advantages over open laparotomy, including less pain, smaller incisions, and shorter recovery. There is no increase in early and late complications [57, 58], and cost and outcome are comparable with those of open resection [59].

  • The laparoscopic approach has advantages over open laparotomy, without increased complications.

17.7 Complications

17.7.1 Fistulas

When a diverticular phlegmon or abscess extends or ruptures into an adjacent organ, fistulas can arise, the most typical being colovesicular fistulas [60]. The incidence of colovesical fistulas in diverticular disease has been reported to range between 2 and 23 % [61, 62]. Such fistulas have a two-to-one male predominance, attributable to protection of the bladder by the uterus, and a 50 % rate of hysterectomy in female patients with colovesical fistulas. The underlying mechanism is the direct extension of a ruptured diverticulum or erosion of a peridiverticular abscess into the bladder. While sigmoid diverticulitis accounts for the underlying pathology in approximately two-thirds of patients, colovesical fistula has also been reported as a result of cancer of the colon or bladder, radiation therapy, or Crohn’s disease [61, 63]. To date the diagnosis of colovesical fistula due to sigmoid diverticulitis remains a challenge, without a gold standard of treatment. Recurrent or persistent urinary tract infections, urinary frequency, dysuria, and hematuria are the most frequent clinical findings. These symptoms are unspecific, however, and thus diagnosis of colovesical fistula may be delayed. Pneumaturia and fecaluria are considered pathognomonic for colovesical fistulas, but these symptoms are not always present. Diagnostic procedures for colovesical fistulas are conducted to prove the existence of the fistula and to delineate the underlying etiology, as this determines further therapeutic strategy. Diagnostic tests and procedures range from the simple poppy seed test to the chromium nuclear study and the Bourne test to abdominal CT and MRI, cystoscopy, and colonoscopy [6466]. Different from advanced cancer resection for colovesical fistula because of sigmoid diverticulitis, sigmoid segment resection and closure of the bladder defect is required for colovescial fistulas. In view of a spontaneous closure rate of only 2 % for colovesical fistulas [67, 68], and inflammatory complications in up to three-quarters of patients [69, 70], the existence of colovesical fistulas should be seen as an indication for surgery. Conservative or endoscopic procedures remain reserved for individual cases.

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Oct 30, 2017 | Posted by in ABDOMINAL MEDICINE | Comments Off on Diverticular Disease
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