Dietary risk
Indication(s) for assessing risk
Mechanism for dietary risk
Suboptimal fluid intake
Assess as needed, especially when:
Low fluid intake results in concentrated (less dilute) urine and high urine supersaturation for specific crystalloid(s)
Urine output less than 2 L or some other output target
Excessive dietary salt (NaCl) intake
Assess as needed, driven by presence of:
Dietary sodium chloride expands extracellular volume and increases urinary calcium and cysteine excretion
Hypercalciuria
Higher urinary sodium or chloride excretion
Patient is prescribed a thiazide diuretic for hypercalciuria
Cystinuria [5]
Assess as needed, driven by presence of:
Carbohydrates may:
Hypercalciuria (refined or simple carbohydrates, caffeine, alcohol)
Increase calcium absorption from GI tract
Hyperuricosuria (fructose, alcohol)
Increase plasma insulin, reducing renal calcium reabsorption
Increase uric acid biosynthesis (fructose in particular)
Caffeine may:
Block c-AMP and thus reduce renal calcium reabsorption
Alcohol may:
Increase osteoclast activity
Increase uric acid biosynthesis
Higher acid load of diet [10]
Assess as needed, driven by presence of:
Unbalanced consumption of alkaline/neutral vs. acid-ash foods can lead to:
Acidic urine
Systemic acidosis and low urine pH
Hypercalciuria
Increased calcium resorption from bone
Hypocitraturia
Increased renal citrate reabsorption
Assess as needed, driven by presence of:
Dietary purines (animal-derived), fructose, and alcohol provide substrate for uric acid biosynthesis
Hyperuricosuria
Precipitation of uric acid crystals in sample (important to note if urinary uric acid excretion is unusually low)
Suboptimal calcium and/or magnesium intake; intake timed apart from meals (especially if from supplements)
Assess in the presence of:
Insufficient calcium intake leads to higher oxalate solubility and absorption from GI tract
Higher oxalate excretion
Lower magnesium excretion
High intake of high-oxalate foods relative to consumption of calcium and/or magnesium
Assess in presence of hyperoxaluria and when oxalate consumption occurs:
High oxalate intake without sufficient calcium leads to higher oxalate content and solubility in GI tract and higher oxalate absorption
In absence of (unopposed by) calcium and/or magnesium sources
By patients prone to malabsorption
By patients with primary hyperoxaluria
Assess in presence of hyperoxaluria
Ascorbic acid is metabolized to oxalate
Some plant-derived dietary supplements provide high-oxalate load
Assess if:
Antibiotics:
Frequent antibiotic use
Target beneficial gut bacteria, including those that may degrade oxalate
Chronic diarrhea
Diarrhea:
Suboptimal intake of prebiotic material
Reduces colonization of beneficial gut bacteria, including those that may degrade oxalate
Low intake of prebiotics (contained largely in the fiber of fruits, vegetables, and whole grains):
Provides insufficient substrate for oxalate-degrading bacteria in GI tract
Table 6.2
Methods for assessing patients’ diets
Method | Description | Advantages | Disadvantages |
---|---|---|---|
Usual intake/diet history | Qualitative method in which patient is asked to recall a typical daily intake pattern, including specific foods and beverages, frequency of consumption, methods of preparation, and portion sizes consumed | Easily obtained | Depends on patient’s ability to provide details |
Patient is usually asked to run through a typical day in chronological order | Accomplished relatively quickly if done by dietitian or other trained professional | Can be challenging for patients whose intake varies significantly from day to day or week to week or whose memory is questionable | |
Identifies longer-term, habitual dietary habits | Portion sizes may be inaccurately described | ||
Reveals lifestyle and other factors related to food intake | Information can be used to quantify usual intakes of specific macro- and micronutrients and food groups | Requires assessor to be able to correctly interpret patient-reported information | |
Relatively low patient burden | |||
24-h recall | Qualitative method in which patient recalls all foods and beverages consumed in the last 24 hours, including quantities, portion sizes, and methods of preparation | Easily obtained | Limited data obtained; may not reflect usual or habitual intake |
Can be completed in person or over the telephone; some nutrient analysis software programs provide modules specifically designed for 24-h recalls | Requires limited memory | Portion sizes may be inaccurately described | |
Information can be used to quantify last 24-h intake of specific macro- and micronutrients and food groups | Requires expertise by assessor to correctly interpret data provided | ||
Low patient burden | |||
Food frequency questionnaire (or food screener) | Written or computerized checklist of foods and beverages which patients complete, usually on their own | Questionnaires for specific medical conditions, groups of patients (e.g., children, adults, racial/ethnic groups), and time frames (e.g., month, year) exist; many are validated against more rigorous diet assessment methods | Depending on length of questionnaire (some are several pages long), patient burden may be quite high |
Foods are usually listed in categories; frequencies are usually listed for patient to identify “daily,” “weekly,” or other consumption | Can be used to quantify intake of specific macro- and micronutrients and food groups | Patient error in completing questionnaire, such as in estimating frequency of intake over a year’s time, is well documented | |
Usually no way to identify food preparation methods | |||
Useful in determining general dietary patterns and trends | Not all questionnaires query about specific portion sizes, resulting in over- or underestimation of intake | ||
Questionnaires designed for specific medical conditions or populations are not reliable when used out of context | |||
Food log, diet record or journal | Patient records all food and beverage consumption for a variable length of time (a day, multiple days, a week) in as much detail as possible | Patient records information as soon as possible after consumption, eliminating errors due to faulty memory | As with other methods, depends on patient’s honesty and ability to accurately record data |
Food scales may be provided to aid in accurately recording amounts prepared and consumed | Data provided can be extremely accurate, so much so that weighed food records are considered as close to a “gold standard” as currently exists | Patient burden is relatively high, especially when food scales are used | |
Data is typically entered into a nutrient analysis software program to obtain detailed information about macro- and micronutrient consumption | Patients may err in recording food quantities | ||
Quality of data may decline in relation to the number of days recorded | |||
Patients may not eat the way they normally eat during the documentation period |
There is no evidence-based, validated dietary “risk profile” for assessing lithogenic risk factors in the diet. A 24-h urine collection or “risk profile ,” though useful in identifying lithogenic risk related to renal function and handling [19], may only suggest the presence of dietary excesses or inadequacies; it is not a surrogate for dietary assessment as many urinary parameters are subject to metabolic control prior to renal handling, such as during digestion, absorption, circulation, and storage. Some stone risk factors that appear in urine are synthesized in vivo by precursors that may or may not be consumed in the diet. By any means – be it by 24-h diet recall, diet history, food frequency questionnaire or screener, weighed diet records, or any other of a number of alternatives – dietary assessment is uniquely subjective and controlled in most ways by the patient. The patient’s willingness and ability to provide accurate information depend on a number of both patient and provider factors, not the least of which include how accepting the patient perceives the provider to be, how well the patient describes his/her intake, and how accurately the provider interprets the information.
People’s dietary habits are inherently personal and frequently linked to cultural and ethnic identity. Patients feel most comfortable providing dietary information in a nonjudgmental, culturally aware, and understanding environment [20, 21]. RDNs and similarly trained nutrition experts are skilled in dietary assessment yet are not widely distributed among urology clinics, where the majority of patients are seen for stone prevention [22]. Thus, non-dietitian providers often include diet in their evaluation. But urologists and others frequently lack the time (which may require >30 min per patient if both assessment and intervention are done) and detailed knowledge about foods, digestion, and absorption to conduct a thorough and meaningful diet assessment. Because of this, urologists have expressed a desire for greater access to dietitians [23].
General dietary assessment
A general dietary assessment may begin by asking the patient if he or she follows any special diet. The words patients use to describe their overall dietary patterns, whether accurate or not, can be useful in interpreting the data obtained. Patients may then be queried about their appetite and whether any changes have occurred recently and about their weight history. Other information obtained during a general dietary assessment may include the extent to which patients eat more or less the same things every day, eat at the same times of day, eat out or bring home take-out foods, use condiments, participate in food preparation, skip meals, snack between meals, use alcohol, and avoid certain foods (and if so, why). Information obtained during the course of the assessment includes: details about where foods are consumed (e.g., home, work, school), portion sizes, methods of preparation, grocery shopping habits, food likes and dislikes, swallowing and dentition issues, food insecurity, knowledge of nutrition, and use of nutritional supplements. If quantification of intake is desired, data may be entered later into a nutrient analysis software program. Alternatively, a RDN may quantify in the clinic the foods and nutrients of interest by estimation, using his/her knowledge of nutritional composition and food tables that provide nutrient content.
Targeted dietary assessment
Assessment may be targeted to the condition under evaluation and is always aimed at identifying the specific dietary mechanism(s) contributing to disease etiology, exacerbation, or risk of recurrence. The following is an analogy of a targeted assessment using the physical therapist (PT) as an example. A patient referred for a specific physical or muscular derangement is not typically assessed by the PT for his/her entire body and musculature as he or she might be if undergoing a general physical assessment. Rather, in the interest of time and efficiency and to address an acute injury or chronic problem, the PT will focus on body areas near to and involved in the problem of interest. In the area of urolithiasis, a targeted dietary assessment by the RDN or other person conducting it may be similarly indicated and should focus around the most common dietary risk factors, driven or informed by the presence of biochemical aberrations (Table 6.1).
Common pitfalls during dietary assessment
Depending on how comprehensive and if targeted to certain foods or not, dietary assessment is frequently not accomplished in a couple of minutes. Without ample time, it is therefore understandable that shortcuts are taken. However, some shortcuts can lead to inaccurate assessment. A common problem in assessing the diets of patients is to ask leading questions, such as, “You don’t eat a lot of salt, do you?” or “Tell me which of these foods (provider hands the patient a list) you eat.” The appearance of judgment or expectation on the assessor’s part could lead to withholding or otherwise inaccurate patient reporting [20]. Thus, open-ended questions about specific foods of interest are best. Another problem is the inaccurate assessment of portion sizes . A patient might say, “I eat a lot of peanuts,” but his/her interpretation of “a lot” – or the assessor’s – could differ vastly from another who uses the same verbiage. Strategies to elicit accurate portion size estimations are widely employed by dietitians and include pictures or photos; synthetic (“fake”) foods; household measuring utensils; plates, bowls, and cups; food packages; and/or follow-up questions that result in the reasonable assurance of correct sizing [24]. Information about frequency of intake is also important. The frequent vs. infrequent intake of “high-risk” foods should be discerned. The patient who “loves spinach” but who only eats it once a month or so is likely to benefit little – if at all – from a restriction of spinach to address her risk of calcium oxalate stones. Yet another mistake is to ask only about meals. Rather than asking what the patient typically eats for breakfast, lunch, and dinner, use open-ended questions, such as, “Tell me about the first time in your day that you eat or drink anything.” This avoids the potential to miss between- and/or after-meal food and beverage intake, which could be significant. Moreover, some patients may follow a “grazing” dietary pattern and not identify with discrete “meals” when queried about them.
Quantification of foods and nutrients
Beyond usual servings per day of certain foods – such as fruits and vegetables, meats, breads and baked goods, calcium-rich foods, and beverages – it is usually also desirable to quantify the intakes of specific nutrients, such as sodium and calcium, in milligrams or grams consumed per day. This requires detailed knowledge of the sources of foods that express these nutrients as well as the amounts they contain. While some may wish to quantify the amount of oxalate consumed, this is problematic due to the extensive variability in the reported oxalate content of foods, to the variable bioavailability of food oxalate, and to variations in human gastrointestinal tract physiology leading to significant differences in oxalate absorption [25]. Although these same problems exist to some degree in quantifying sodium and calcium, food values for these minerals are quite stable across multiple data sets .
Link Lithogenic Risk Factors to Results of the Diet Assessment
There is no standard diet or eating plan that is universally effective for all stone formers. Even when patients form the same type of stone, risk factors (i.e., causes) frequently differ, if not in the specific risk factor, then in its magnitude of severity. Targeted nutrition therapy is therefore appropriate. While it might be tempting to address each and every dietary “indiscretion” uncovered in dietary assessment, this may result in overwhelming the patient or providing useless recommendations. The goal of the diet assessment is to provide recommendation(s) with the greatest possible impact on stone disease. Dietary risk factors should be linked directly to biochemical or other evidence exposing stone risk. For example, high sodium intake revealed from the diet assessment would be linked to high urinary calcium excretion (if observed), and lower salt intake would be a priority. However, high sodium intake in the absence of high urinary calcium excretion would have lower priority for intervention and would warrant only a comment, perhaps, about future risk. Plenty of patients have high sodium intake by standard definitions (e.g., Dietary Reference Intakes [26] – see Appendix 5) but have normal urinary calcium excretion, even in repeated 24-h urine collections. This could be due to a regular exercise regimen that induces ample dermal sodium excretion, to the presence of chronic calcium malabsorption, or to higher fecal sodium excretion. Focusing on sodium reduction in such scenarios could diminish the patient’s enthusiasm for other dietary changes that are capable of real risk reduction or for dietary stone prevention as a whole. Moreover, reducing sodium intake in these situations would not reduce the patient’s stone risk. This could deflate patients’ expectations for the potential of diet to reduce stone risk. Below, common urinary risk factors for stones and links to dietary risk factors are reviewed.