IDFa
AHA/NHLBIb
AACEa
NCEPb ATPIII
EGIRa
WHOa
Required criteria
Insulin resistance (or fasting insulin) in top 25% or type 2 diabetes mellitus
x
x
Glucose >100 mg/dL or 2 h glucose ≥140 mg/dL
x
High risk for insulin resistance or BMI >25 or waist ≥102 cm (men) or ≥88 cm (women)
x
Ethnic-based waist, European, ≥94 cm (men) or ≥80 cm (women); Asian, ≥90 cm (men) or ≥80 cm (women)
x
Non-required criteria, at least 2 or 3 :
Glucose, ≥100 mg/dLc
x
x
x
x
x
2 h glucose, ≥140 mg/dL
x
HDL, <40 mg/dL
x
HDL, ≤35 mg/dL (men) or ≤40 mg/dL (women)
x
HDL, <40 mg/dL (men) or <50 mg/dL (women)
x
x
x
x
Triglycerides, ≥150 mg/dL
x
x
x
x
x
x
Obesity, waist ≥102 cm (men or ≥88 cm (women)
x
x
Obesity, waist/hip ratio >0.9 (men) or >0.85 (women) or BMI ≥30
x
Obesity, waist/hip ratio ≥94 cm (men) or ≥80 cm (women) or BMI ≥30
x
Hypertension, ≥130/85 mmHg
x
x
x
x
Hypertension, ≥140/90 mmHg
x
x
Microalbuminuria, ≤20 mcg/min or albumin/creatinine ratio ≥30 μg/mg
x
Urolithiasis and Diabetes Mellitus
Diabetes mellitus is one of the major manifestations of the metabolic syndrome. Diabetes mellitus type 2 (also known as type 2 diabetes ) is a chronic metabolic disorder that develops over time and is characterized by hyperglycemia, insulin resistance, and relative insulin insufficiency [1]. The link between kidney stone disease and diabetes is complex and is associated with both uric acid stones and calcium oxalate stones [6]. Uric acid stones are more commonly seen in patients with diabetes. The rate of uric acid stones in patients with diabetes is around 30–40% compared to a rate of 5–10% in the general population [7]. Risk factors for uric stone formation are hyperuricosuria, acidic urine, and low urine volume. Risk factors for calcium oxalate stone formation are low urine volume, high urinary excretion of calcium and/or oxalate, and low urinary excretion of magnesium and/or citrate. These conditions may occur as a result of idiopathic, genetic, and/or lifestyle causes. In the presence of insulin resistance and obesity – common sequelae in patients with diabetes – there is increased uric acid excretion [8]. Also, when ammoniagenesis is impaired, which is common in diabetes, urinary pH is reduced, favoring the formation of uric acid stones. Notably, obesity – with or without diabetes – is linked to increased renal excretion of calcium and uric acid as well as urine acidity, all of which increase the risk of both uric acid and calcium oxalate stone formation [7, 9].
Nutritional Management of Diabetes
Medical nutrition therapy (MNT) is recommended for people with type 1 and type 2 diabetes as part of their overall medical treatment plan [10]. Individualized MNT is provided by a registered dietitian nutritionist (RDN) who is knowledgeable in diabetes. For adults with diabetes, the aim of MNT is to emphasize eating a variety of nutrient-dense foods, in appropriate serving sizes, so that patients may realize and sustain favorable body weight goals, achieve good glycemic control, meet lipid and blood pressure goals, and postpone or avert diabetes and its complications. These goals require individualization as patients are quite heterogeneous with respect to their expression of the above.
Energy balance and distribution of macronutrients
For adults with type 2 diabetes who are overweight or obese, reducing energy intake while retaining a healthy and nutrient-adequate eating pattern is recommended. Even a moderate amount of weight loss may improve glycemia, blood pressure, and blood lipids, especially among those in the early stage of the diabetic disease process. To achieve a reasonable amount of weight loss, MNT, physical activity, and/or behavior change is encouraged [11]. As evidence suggests there is not a single dietary plan that is appropriate for all people with diabetes, the distribution of dietary macronutrients as well as micronutrients should be based on an individualized assessment of food preferences, eating patterns, and metabolic goals [12]. The Dietary Reference Intakes (DRIs) [13] – which include recommended dietary allowances (RDAs) , adequate intakes (AIs) , estimated safe and adequate daily dietary intakes (ESADDIs) , and tolerable upper intake levels (ULs) (see Appendix 5 for a description and table of DRIs) – provide a general framework from which to individualize each patient’s nutritional goals. According to the DRIs , the acceptable macronutrient distribution range for adults is 45–65% of total energy needs from carbohydrates, 10–35% from protein, and 20–35% from fat. Note that the wide ranges for each of these macronutrients include those that are recommended for patients with diabetes, underscoring the need for individualized dietary recommendations .
Carbohydrate/dietary fiber
Both quantity and type of carbohydrate influence blood glucose levels . The total amount of carbohydrate eaten is the primary predictor of glycemic response. Monitoring carbohydrate amounts is thus a useful strategy for improving postprandial glucose control. Carbohydrates from fruits, whole grains, legumes, vegetables, and dairy are recommended. Other sources of carbohydrates, such as those with added sodium, sugar, and fats, are not recommended or, if consumed, recommended in lower amounts [10, 12]. Common lore suggests that patients with diabetes should limit their intake of carbohydrates. Indeed, many patients erroneously believe they should eliminate fruits and/or starchy vegetables from their diets. But without adequate carbohydrate intake, protein is used for energy as opposed to being used to synthesize new proteins critical for maintaining homeostasis and immune function. Thus, complete avoidance of these foods may compromise the nutritional quality of the diet and overall health. Instead of eliminating, strategies for good glucose control include the distribution of carbohydrates throughout the day, consuming carbohydrate-rich foods with meals, and avoiding concentrated carbohydrate doses. A variety of methods for diabetes meal planning are presented to patients by RDNs or diabetes educators and include the plate method, carbohydrate counting, and glycemic index [13]. Fiber, which can reduce the impact of food-derived glucose on blood glucose, is recommended in the same amounts as for the general population. Fiber is nondigestible and therefore provides little to no energy. Patients with diabetes should aim for about 25 (adult women) and 38 (adult men) grams of fiber daily. This amounts to approximately 14 g of fiber/1,000 kcals/day [14].
Protein
The amount of protein intake required to optimize glycemic control among those with diabetes is controversial, but all experts agree that protein intake goals should be individualized within the DRI ranges [14]. People with diabetes, including those with diabetic kidney disease, should not reduce their dietary protein intake unless it is specifically advised; doing so could alter glycemic control and negatively impact kidney function, cardiovascular risk, and bone status [15]. Meats of all kinds, fish, poultry, cheeses, and lower-fat dairy foods, eggs, and some plant-based foods are all good sources of high biological value protein and should be encouraged in moderation .