Cytokines as Active Factors in Minimal Change Nephrotic Syndrome

Authors

IL-1

IL-2

sIL-2R

IL-4

IL-5

IL-7

IL-8

IL-10

IL-12

IL-13

IL-18

IFN-γ

TNF-α

VEGF

MCD

Garin [89]

↑

Cho [76]

19?

↑

↔

Wada [110]

Ishimoto [17]

MCD and other glomerulopathies

Suranyi [63]

↔

↑**

Hulton [60]

↑

Cheong [119]

↑*

Neuhaus [59]

↔

↑

↑2

Stefanovic [65]

Daniel [58]

↔

↑

↓

↔

↑ ns

↔

No biopsy data

Bustos [75]

↔

↑

Yap [87]

55?

Lama [61]

↔

Shimoyama [64]

↔

Kanai [109]

↑*

Tain [96]

↑

Kanai [73]

↑

Webb [116]

↔

Kanai [66]

↔

↑

↔

↑

↔

Mishra [95]

↑

Printza [62]

↔

↑

↓

Sook Youn [69]

↑

↔

Wasilewska [74]

↑

N number of patients, MCD minimal change disease, ↑ increased values compared to those of healthy controls, ↓ decreased values compared to those of healthy controls, ↔ values not different from those of healthy controls, ND not detected, * increased values in relapse compared to those in remission (no comparison with healthy controls included), ** increased values when compared nephrotic group to healthy controls but no when considers only MCD vs healthy controls (n 5), 2- elevated levels in both relapse and remission compared to controls,? unclear number of patients to whom serum cytokines were measured, ns no statistical significance

Table 8.2

Cytokine levels in serum from patients with idiopathic nephrotic syndrome during remission

Authors	N	IL-1	IL-2	sIL-2R	IL-4	IL-5	IL-7	IL-8	IL-10	IL-12	IL-13	IL-18	IFN-γ	TNF-α	VEGF
MCD
Garin [89]	7							↔
Cho [76]	19?							↔						↔
Wada [110]	?
Ishimoto [17]	9										ND
MCD and other glomerulopathies
Suranyi [63]	34?
Hulton [60]	20		ND	↔
Cheong [119]	16														↓*
Neuhaus [59]	15			↔	↑			↔					↑
Stefanovic [65]	9									ND			ND
Daniel [58]	18	↔	↔	↔	↔			↔	↔				↔	↔
No biopsy data
Bustos [75]	14	↔												↔
Yap [87]	?										ND
Lama [61]	18		ND	↔
Shimoyama [64]	9		↔		↔				↔				↔	↔
Kanai [109]	9?							↔
Tain [96]	15										↑2
Kanai [73]	18?						↑
Webb [116]	13														↔
Kanai [66]	14				↔	↔			↑	↔	↑		↔	↔
Mishra [95]	40										↔
Printza [62]	23		↔		↑						↑	↑	↔
Sook Youn [69]	17				↔	↔			↔
Wasilewska [74]	26						↔

N number of patients, MCD minimal change disease, ↑ increased values compared to those of healthy controls, ↓ decreased values compared to those of healthy controls, ↔ values not different from those of healthy controls, ND not detected, * decreased values in remission compared to those in relapse (no comparison with healthy controls included), 2- elevated levels in relaspe and remission compared to controls,? unclear number of patients to whom serum cytokines were measured

Table 8.3

Cytokine levels in culture supernatants from patients with idiopathic nephrotic syndrome during relapse

Authors	N	IL-1	IL-2	sIL-2R	IL-4	IL-6	IL-8	IL-10	IL-12	IL-13	IL-18	IFN-γ	TNF-α	Mitogen	Time (hours)
MCD
Hinoshita [82]	12		↓											PHA	48
Saxena [81]	10	↓	↑											PHA	48
Matsumoto [79]	7							↓						No	24
	7							↓						LPS	24
Matsumoto [80]	5						↑*							No	24
	5						↑*							LPS	24
Matsumoto [77]	8								↑					No	24
	8								↑					LPS	24
Matsumoto [78]	8										↑			No	24
	8										↑			LPS	24
Ishimoto [17]	8									ND				No	72
MCD and other glomerulopathies
Suranyi [63]	34?	↔	↔									↔	↑	ConA	72
Suranyi [63]	34?	↑	↔									↔	↑	PHA	72
Neuhaus [59]	7		ND		ND		↑ns					ND		No	24
			↑		↑		↔							PMA	24
					↑		↔					↔		PMA	72
Stefanovic [65]	11		ND											No	72
			↔									↓		PWM	72
												↔		ConA	72
Stachowski [83]	25													No	18
Stachowski [83]	25		↓		↔			↑				↓		TT	18
Bakr [86]	21												↑	ConA	48
No biopsy data
	11												↑	No	24
Bustos [75]	7					↔							↑	Actino.	24
	5	↔												Actino.	24
Cho [85]	22				↔									No	48
					↑									PMA+	48
					↑									PHA	48
Lama [61]	18		↑	↑	↑			↑				↑	↑	PHA	72
Kang [84]	19				↑									PHA	48

N number of patients, MCD minimal change disease, ↑ increased values compared to those of healthy controls, ↓ decreased values compared to those of healthy controls, ↔ values not different from those of healthy controls, ND not detected, ? number of patients included not clear, ns no statistical significance, PHA phytohemagglutinin, LPS lipopolysaccharide, ConA concanavalin A, PMA phorbol 12-myristate 13-acetate, TT tetanus toxoid, Actino. actinomycin D, PWM pokeweed mitogen. * MCD patients in relapse and remission were compared as a group to healthy controls. Increased IL-8 was not significantly different to controls

Table 8.4

Cytokine levels in culture supernatants from patients with idiopathic nephrotic syndrome during remission

Authors	N	IL-2	IL-4	IL-8	IL-10	IL-12	IL-13	IL-18	IFN-γ	Mitogen	Time (hours)
MCD
Hinoshita [82]	12?	↓								PHA	48
Matsumoto [79]	7				↓					No	24
	7				↓					LPS	24
Matsumoto [80]	5			*						No	24
	5			*						LPS	24
Matsumoto [77]	8					↔				No	24
	8					↔				LPS	24
Matsumoto [78]	8							↔		No	24
	8							↔		LPS	24
Ishimoto [17]	8						ND			No	72
MCD and other glomerulopathies
Neuhaus [59]	8	ND	ND	↔					ND	No	24
		↔	↔	↔						PMA	24
			↔	↔					↔	PMA	72
Stefanovic [65]	9					ND			ND	No	72
						↔			↔	PWM	72
						↔			ND	ConA	72
Stachowski [83]	?									No	18
Stachowski [83]	?	↑ < div class='tao-gold-member'> Only gold members can continue reading. Log In or Register to continue Share this: Click to share on Twitter (Opens in new window) Click to share on Facebook (Opens in new window) Related posts: History of Research on Pathogenesis of Idiopathic Nephrotic Syndrome Regulatory T Cells and Oxidative Stress in Minimal Change Nephropathy Podocytes as a Direct Target of Drugs Used in Idiopathic Nephrotic Syndrome Co-stimulatory Molecule CD80 (B7.1) in MCNS Cationic Bovine Serum Albumin as Cause of Membranous Nephropathy: From Mice to Men The Role of c-mip in the Pathogenesis of Minimal Change Nephrotic Syndrome Stay updated, free articles. Join our Telegram channel Tags: Molecular Mechanisms in the Pathogenesis of Idiopathic Nephrotic Syndrome Jul 4, 2016 \| Posted by admin in NEPHROLOGY \| Comments Off on Cytokines as Active Factors in Minimal Change Nephrotic Syndrome Full access? Get Clinical Tree Get Clinical Tree app for offline access Get Clinical Tree app for offline access