Comorbidity
Number
Percentage (%)
Median age (years)
Angina
1845
16.9
71.3
MI in past 3 months
339
3.1
70.7
MI > 3 months ago
1304
11.9
70.8
CABG/ angioplasty
837
7.7
69.0
Cerebrovascular disease
1,177
10.8
71.1
Diabetes (not listed as PRD)
977
9.1
70.9
COPD
855
7.9
70.8
Liver disease
329
3.0
60.0
Claudication
957
8.7
70.6
Ischemic/neuropathic ulcers
410
3.7
62.6
Angioplasty/vascular graft
411
3.8
71.4
Amputation
248
2.3
61.3
Smoking
1629
15.3
61.2
Malignancy
1457
13.3
72.0
Hypertension is common in this population, and good control should be achieved to minimize perioperative instability. Additionally, the patient should be instructed to schedule hemodialysis the day prior to the surgery, as well as counseled on what to do regarding their regular medications. It is somewhat controversial, but in general, angiotensin-converting enzyme inhibitors and angiotensin receptor blockers are not given on the day of surgery because of the risk of significant hypotension at induction of anesthesia.
In the patient with diabetes, a balance must be achieved between best controls of blood glucose while minimizing the risks of hypoglycemia. While insulin doses should be tailored to each individual patient, basic guidelines can be followed:
Night before the procedure:
Neutral Protamine Hagedorn (NPH)/Levemir and mixed insulins: 100 % of usual dose
Lantus: 80–100 % of usual dose
Morning of the procedure:
NPH/Levemir: 50 % of usual dose
Lantus: 80 % of usual dose
Mixed insulin: 33 % of usual dose
Regular/short-acting insulin: HOLD
Routine labs may also be helpful in the preoperative setting to rule out major metabolic derangements, including a complete blood count, a chemistry, and a coagulation panel with repeat evaluation of pertinent labs on the morning of the procedure.
Same-Day Evaluation
Most procedures to create hemodialysis access are outpatient procedures with patients arriving 1–2 h prior to the planned procedure start. The preanesthesia interview in the preoperative holding area is one of the most important phases in preparing the patient for the administration of anesthesia. The anesthesia team should review the preanesthesia evaluation completed in the preanesthesia clinic and confirm that the patient’s general condition has not changed since the preanesthesia clinic evaluation. Intravenous access and blood pressure monitoring should be avoided in the arteriovenous (AV) access arm. Obtaining peripheral venous access may be difficult, and SonoSite may be necessary to identify and guide access. In those patients with an indwelling catheter, it may be accessed, although this is avoided in general due to fear of increased infectious complications.
Special Considerations: Patients with Chronic Kidney Disease Versus End-Stage Renal Disease
In patients with CKD who are not yet on hemodialysis, it is important to elicit information regarding the volume and regularity of urine production with special attention to those who report a recent drop in volume or frequency. This may indicate a recent worsening of their renal function which may necessitate closer attention to potassium changes or fluid management during the procedure. For patients with ESRD on dialysis, it is important to establish when the patient underwent dialysis last. Ideally, the patient should have hemodialysis 12–24 h prior to the procedure, as the patient should ideally be completely or near completely at a normal physiological status and baseline dry weight at the time of anesthetic administration and the procedure. Close attention should be paid to establishing the correct “dry weight” for the patient, i.e., the weight at which they are euvolemic. If the patient is above their dry weight preoperatively, they risk pulmonary edema and poorly controlled hypertension perioperatively. If under their dry weight, they may become profoundly hypotensive during anesthesia [4]. Additionally, the regularity at which the patient has recently undergone dialysis is also important because a single session of dialysis may not normalize the patient that has missed more than one session, particularly with regard to fluid status. Similarly, it is important to ask if the patient tolerated the last hemodialysis session. If the patient did not tolerate the last hemodialysis session, the session was terminated prematurely or the patient skipped a regular session because of feeling ill; this warrants further investigation along with an assessment of laboratory abnormalities that may necessitate canceling or rescheduling the procedure.
Preoperative Laboratory Data
Verification of certain laboratory data is critical to check on the day of the procedure as these patients are subject to day-to-day changes.
Potassium
Patients with CKD or ESRD often have higher serum potassium levels than patients without renal dysfunction. Hyperkalemia is essential to diagnose and treat because it can be life-threatening due to the effect of increased potassium on electrical activity of the heart. Therefore, hyperkalemia may produce ECG changes, starting with peaked T waves and progressing to P wave widening and flattening, and as the PR segment lengthens, the P waves disappear. There are no recommendations for absolute levels of preoperative potassium levels that are considered safe; thus there is variability between hospital protocols in terms of which procedures need to be canceled and rescheduled based on findings of hyperkalemia on the day of the procedure. It is worth noting that the serum potassium level is closely related with serum pH; thus if the patient is acidotic, reevaluation of serum potassium level must be considered after pH is corrected. At our institution, a potassium level higher than 6.0 mmol/L prompts a discussion between the anesthesiologist and surgeon regarding the need for urgent hemodialysis prior to the procedure. One additional consideration is that venous potassium levels can sometimes falsely be higher than arterial levels, and obtaining an arterial blood sample may be useful in confirming the correct true potassium level [5].
Occasionally, some patients have a lower preoperative potassium level (<3.5 mmol/L). A lower potassium level is not as dangerous for the patient as much as higher potassium levels. Therefore, correction is required only if it is associated with frequent cardiac arrhythmias or with significant ECG changes such as QT prolongation. It is extremely difficult to correct hypokalemia in a patient with ESRD, and a nephrologist or cardiologist should be involved in the process to avoid overcorrection and possible cardiac effects.