Tharani Mahesan Perhaps the most common presentation to a urology clinic is the male patient with lower urinary tract symptoms (LUTS). Patients may present to a general urology clinic, via a ‘raised prostate specific antigen (PSA) clinic’ or as a result of a failed trial without catheter (TWOC). Many urology units are now striving to offer a merged ‘one‐stop’ clinic for all such conditions, and LUTS is a condition that lends itself well to the ethos of ambulatory care. In a well‐organised service, it should be possible to offer all necessary investigations and assessments in order to reach a diagnosis and plan treatment for the male LUTS patient. Lower urinary tract symptoms may be divided into storage and voiding symptoms. This differentiation is made on patient history and dictates appropriate investigation. In patients with solely storage symptoms (urgency of urination, frequency, and nocturia), diagnoses such as infection, overactive bladder (OAB) syndrome, or detrusor overactivity (DO) should be considered. Patients with voiding symptoms (hesitancy, poor flow, intermittency, double voiding) and those with mixed voiding and storage symptoms are more likely to have bladder outflow obstruction as the underlying cause. Bladder outflow obstruction must be considered in men presenting with urinary tract infection, orchitis, acute urinary retention, bladder stones, and also those with high post‐void residual volumes in the bladder and indications of chronic urinary retention. Bladder outflow obstruction is, to a degree, considered synonymous with benign prostatic obstruction (BPO) and benign prostatic hyperplasia (BPH). Indeed, 50% of men have BPH by the age of 60. However, other causes of obstruction are not infrequent and should be excluded. Other diagnoses to consider should include urethral stricture disease, bladder neck stenosis, detrusor failure, and obstruction due to prostate cancer or urothelial cancer. Table 15.1 Distinguishing between differential diagnoses. Several tools can be utilised in distinguishing between these aetiologies, and the findings of such investigations are summarised in Table 15.1. Crucial in any urology clinic is the history from the patient. It is important to establish the nature, duration, and bother of his LUTS. One should attempt to elicit which aspect of his LUTS he finds most bothersome, although other tools will also help to elucidate that. Table 15.2 Urine dipstick testing interpretation. The patient’s regular doctor may have commenced medications and it is important to establish what those are. Enquire about past medical history as well as associated medications because several widely used medications are known to have urological consequences despite being prescribed for non‐urological problems (e.g., alpha‐blocker medication maybe prescribed for blood pressure control and amitriptyline is associated with urinary retention). It must be established whether any previous urological surgery has been undertaken and consideration should be given to prostate cancer if there is a significant family history. It is important to identify any ‘red‐flag’ symptoms such as visible haematuria, weight loss, or anorexia. Basic investigations should include urine dipstick testing (see Table 15.2), serum PSA, and urea and electrolytes testing to assess renal function. Perhaps most important is to elicit the patient’s expectations around the referral. Many are concerned about the risk of prostate cancer and steps should be taken to prove the absence of such disease in order to offer reassurance. A urine dip is a non‐invasive, easily available bedside test that can be used to identify other causes of LUTS. An irregular prostate on digital rectal exam (DRE) may be an indication of prostate cancer and requires prompt investigation with a PSA and MRI in order to exclude a diagnosis of prostate cancer. A prostate exam also provides clinicians with an idea of prostate size. This can be useful later in determining choice of surgical intervention. Clinicians should remember that PSA can be artificially elevated in chronic retention and urinary tract infection. Invasive investigations such as flexible cystoscopy can produce appreciable but transient PSA elevations for up to six weeks afterwards.
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An Ambulatory Approach to Benign Prostatic Obstruction
Alternative diagnosis to BPO as a cause of LUTS
Investigations
Bladder neck stenosis
Should be considered in men who have undergone previous transurethral resection of the prostate (TURP) or radical prostatectomy.
Can be diagnosed on flexible cystoscopy.
Urethral stricture
Very poor Qmax
Classic appearance of flat flow rate on uroflowmetry
Should be considered in men with previous history of stricture, radiotherapy or trauma but can be present without.
Can be diagnosed on flexible cystoscopy.
Prostate cancer
Should be considered as a potential diagnosis in all men >50 years of age.
Digital rectal exam (DRE) may demonstrate nodules, asymmetry or a firm prostate.
Raised PSA (>3.5 ng/ml).
Check for family history.
Investigate further with magnetic resonance imaging (MRI) and consideration of biopsy.
‘Bladder failure’ aka detrusor underactivity (DU)
Should be considered in men re‐presenting after prior bladder outlet obstruction (BOO) surgery.
Urodynamic testing will demonstrate low voiding pressure, intermittent flow and incomplete bladder emptying. A calculated Bladder Contractility Index <100 is considered diagnostic.
Further Assessment and Investigations
History
Outcome of urine dipstick analysis
Action
Blood
Microscopic haematuria can indicate the presence of a urothelial cancer.
Patients with this require investigation with a flexible cystoscopy and upper tract imaging. Urine cytology can also be offered.
Glucose
This may indicate a diagnosis of diabetes mellitus and predispose to symptoms such as frequency and nocturia. The patient’s regular doctor may need to investigate this further prior to urological intervention.
Leucocytes +/− nitrite
If this finding is associated with symptoms of dysuria and irritative LUTS may be associated urinary tract infection. In such instances a mid‐stream urine sample should be sent for culture and antibiotics commenced.
Urine Dipstick Testing
Prostate Examination and PSA
Uroflowmetry